Science & Technology

“There are very few specific or targeted inhibitors that are used in the treatment of brain cancer. There’s really a dire need for new therapies and new ideas,” says MIT Associate Professor Michael Hemann. The background of this image shows nanoparticles (red) being taken up in the brain with glioblastoma (in green). Nuclear DNA is in blue; tumor-associated macrophages in white. Image: National Cancer Institute/Yale Cancer Center.

By cutting off a process that cancerous cells rely, researchers from MIT have identified a possible new strategy for halting brain tumors.

MIT biologists have discovered a fundamental mechanism that helps brain tumors called glioblastomas grow aggressively. After blocking this mechanism in mice, the researchers were able to halt tumor growth.

The researchers also identified a genetic marker that could be used to predict which patients would most likely benefit from this type of treatment. Glioblastoma is usually treated with radiation and the chemotherapy drug temozolamide, which may extend patients’ lifespans but in most cases do not offer a cure.

“There are very few specific or targeted inhibitors that are used in the treatment of brain cancer. There’s really a dire need for new therapies and new ideas,” says Michael Hemann, an associate professor of biology at MIT, a member of MIT’s Koch Institute for Integrative Cancer Research, and a senior author of the study.

Drugs that block a key protein involved in the newly discovered process already exist, and at least one is in clinical trials to treat cancer. However, most of these inhibitors do not cross the blood-brain barrier, which separates the brain from circulating blood and prevents large molecules from entering the brain. The MIT team hopes to develop drugs that can cross this barrier, possibly by packaging them into nanoparticles.

The study, which appears in Cancer Cell on September 28, is a collaboration between the labs of Hemann; Jacqueline Lees, associate director of the Koch Institute and the Virginia and D.K. Ludwig Professor for Cancer Research; and Phillip Sharp, an MIT Institute Professor and member of the Koch Institute. The paper’s lead authors are former MIT postdoc Christian Braun, recent PhD recipient Monica Stanciu, and research scientist Paul Boutz.

Too much splicing

Several years ago, Stanciu and Braun came up with the idea to use a type of screen known as shRNA to seek genes involved in glioblastoma. This test involves using short strands of RNA to block the expression of specific genes. Using this approach, researchers can turn off thousands of different genes, one per tumor cell, and then measure the effects on cell survival.

One of the top hits from this screen was the gene for a protein called PRMT5. When this gene was turned off, tumor cells stopped growing. Previous studies had linked high levels of PRMT5 to cancer, but the protein is an enzyme that can act on hundreds of other proteins, so scientists weren’t sure exactly how it was stimulating cancer cell growth.

Further experiments in which the researchers analyzed other genes affected when PRMT5 was inhibited led them to hypothesize that PRMT5 was using a special type of gene splicing to stimulate tumor growth. Gene splicing is required to snip out portions of messenger RNA known as introns, that are not needed after the gene is copied into mRNA.

In 2015, Boutz and others in Sharp’s lab discovered that about 10 to 15 percent of human mRNA strands still have one to three “detained introns,” even though they are otherwise mature. Because of those introns, these mRNA molecules can’t leave the nucleus.

“What we think is that these strands are basically an mRNA reservoir. You have these unproductive isoforms sitting in the nucleus, and the only thing that keeps them from being translated is that one intron,” says Braun, who is now a physician-scientist at Ludwig Maximilian University of Munich.

In the new study, the researchers discovered that PRMT5 plays a key role in regulating this type of splicing. They speculate that neural stem cells utilize high levels of PRMT5 to guarantee efficient splicing and therefore expression of proliferation genes. “As the cells move toward their mature state, PRMT5 levels drop, detained intron levels rise, and those messenger RNAs associated with proliferation get stuck in the nucleus,” Lees says.

When brain cells become cancerous, PRMT5 levels are typically boosted and the splicing of proliferation-associated mRNA is improved, ultimately helping the cells to grow uncontrollably.

Predicting success

When the researchers blocked PRMT5 in tumor cells, they found that the cells stopped dividing and entered a dormant, nondividing state. PRMT5 inhibitors also halted growth of glioblastoma tumors implanted under the skin of mice, but they did not work as well in tumors located in the brain, because of the difficulties in crossing the blood-brain barrier.

Unlike many existing cancer treatments, the PRMT5 inhibitors did not appear to cause major side effects. The researchers believe this may be because mature cells are not as dependent as cancer cells on PRMT5 function.

The findings shed light on why researchers have previously found PRMT5 to be a promising potential target for cancer treatment, says Omar Abdel-Wahab, an assistant member in the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, who was not involved in the study.

“PRMT5 has a lot of roles, and until now, it has not been clear what is the pathway that is really important for its contributions to cancer,” says Abdel-Wahab. “What they have found is that one of the key contributions is in this RNA splicing mechanism, and furthermore, when RNA splicing is disrupted, that key pathway is disabled.”

The researchers also discovered a biomarker that could help identify patients who would be most likely to benefit from a PRMT5 inhibitor. This marker is a ratio of two proteins that act as co-factors for PRMT5’s splicing activity, and reveals whether PRMT5 in those tumor cells is involved in splicing or some other cell function.

“This becomes really important when you think about clinical trials, because if 50 percent or 25 percent of tumors are going to have some response and the others are not, you may not have a way to target it toward those patients that may have a particular benefit. The overall success of the trial may be damaged by lack of understanding of who’s going to respond,” Hemann says.

The MIT team is now looking into the potential role of PRMT5 in other types of cancer, including lung tumors. They also hope to identify other genes and proteins involved in the splicing process they discovered, which could also make good drug targets.

Spearheaded by students and postdocs from several different labs, this project offers a prime example of the spirit of collaboration and “scientific entrepreneurship” found at MIT and the Koch Institute, the researchers say.

“I think it really is a classic example of how MIT is a sort of bottom-up place,” Lees says. “Students and postdocs get excited about different ideas, and they sit in on each other’s seminars and hear interesting things and pull them together. It really is an amazing example of the creativity that young people at MIT have. They’re fearless.”

The research was funded by the Ludwig Center for Molecular Oncology at MIT, the Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund, the National Institutes of Health, and the Koch Institute Support (core) Grant from the National Cancer Institute.

Publication: Christian J. Braun, et al., “Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma,” Cancer Cell, 2017; DOI:10.1016/j.ccell.2017.08.018

Source: Anne Trafton, MIT News

Olivine is the most abundant mineral in Earth’s upper mantle, which comprises the bulk of the planet’s tectonic plates. (Photo: Olivine xenoliths in basalt, John St. James/Flickr)

New research from the University of Pennsylvania gives scientists a better idea of olivine’s strength, with implications for how tectonic plates form and move.

No one can travel inside the earth to study what happens there. So scientists must do their best to replicate real-world conditions inside the lab.

“We are interested in large-scale geophysical processes, like how plate tectonics initiates and how plates move underneath one another in subduction zones,” said David Goldsby, an associate professor at the University of Pennsylvania. “To do that, we need to understand the mechanical behavior of olivine, which is the most abundant mineral in the upper mantle of the earth.”

Goldsby, teaming with Christopher A. Thom, a doctoral student at Penn, as well as researchers from Stanford University, the University of Oxford and the University of Delaware, has now resolved a long-standing question in this area of research. While previous laboratory experiments resulted in widely disparate estimates of the strength of olivine in the lithospheric mantle, the relatively cold and therefore strong part of Earth’s uppermost mantle, the new work, published in the journal Science Advances, resolves the previous disparities by finding that, the smaller the grain size of the olivine being tested, the stronger it is.

Because olivine in Earth’s mantle has a larger grain size than most olivine samples tested in labs, the results suggest that the mantle, which comprises up to 95 percent of the planet’s tectonic plates, is in fact weaker than once believed. This more realistic picture of the interior may help researchers understand how tectonic plates form, how they deform when loaded with the weight of, for example, a volcanic island such as Hawaii, or even how earthquakes begin and propagate.

For more than 40 years, researchers have attempted to predict the strength of olivine in the earth’s lithospheric mantle from the results of laboratory experiments. But tests in a lab are many layers removed from the conditions inside the earth, where pressures are higher and deformation rates are much slower than in the lab. A further complication is that, at the relatively low temperatures of Earth’s lithosphere, the strength of olivine is so high that it is difficult to measure its plastic strength without fracturing the sample. The results of existing experiments have varied widely, and they don’t align with predictions of olivine strength from geophysical models and observations.

In an attempt to resolve these discrepancies, the researchers employed a technique known as nanoindentation, which is used to measure the hardness of materials. Put simply, the researchers measure the hardness of a material, which is related to its strength, by applying a known load to a diamond indenter tip in contact with a mineral and then measuring how much the mineral deforms. While previous studies have employed various high-pressure deformation apparatuses to hold samples together and prevent them from fracturing, set-ups that make measurements of strength challenging, nanoindentation does not require a complex apparatus.

“With nanoindentation,” Goldsby said, “the sample in effect becomes its own pressure vessel. The hydrostatic pressure beneath the indenter tip keeps the sample confined when you press the tip into its surface, allowing the sample to deform plastically without fracture, even at room temperature.”

Performing 800 nanoindentation experiments in which they varied the size of the indentation by varying the load applied to the diamond tip pressed into the sample, the research team found that the smaller the size of the indent, the harder, and thus stronger, olivine became.

​​​​​​​“This indentation size effect had been seen in many other materials, but we think this is the first time it’s been shown in a geological material,” Goldsby said.

Looking back at previously collected strength data for olivine, the researchers determined that the discrepancies in those data could be explained by invoking a related size effect, whereby the strength of olivine increases with decreasing grain size of the tested samples. When these previous strength data were plotted against the grain size in each study, all the data fit on a smooth trend which predicts lower-than-thought strengths in Earth’s lithospheric mantle.

In a related paper by Thom, Goldsby and colleagues, published recently in the journal Geophysical Research Letters, the researchers examined patterns of roughness in faults that have become exposed at the earth’s surface due to uplift and erosion.

“Different faults have a similar roughness, and there’s an idea published recently that says you might get those patterns because the strength of the materials on the fault surface increases with the decreasing scale of roughness,” Thom said. “Those patterns and the frictional behavior they cause might be able to tell us something about how earthquakes nucleate and how they propagate.”

In future work, the Penn researchers and their team would like to study size-strength effects in other minerals and also to focus on the effect of increasing temperature on size effects in olivine.

Goldsby and Thom coauthored the study with Kathryn M. Kumamoto of Stanford; David Wallis, Lars N. Hansen, David E. J. Armstrong and Angus J. Wilkinson of Oxford University; and Jessica M. Warren of Delaware.

The work was supported by the Natural Environment Research Council (Grant NE/M000966/1) and National Science Foundation (grants 1255620, 1464714 and 1550112).

Publication: Kathryn M. Kumamoto, et al., “Size effects resolve discrepancies in 40 years of work on low-temperature plasticity in olivine,” Science Advances 13 Sep 2017: Vol. 3, no. 9, e1701338; DOI: 10.1126/sciadv.1701338

Source: Katherine Unger Baillie, University of Pennsylvania

Using NASA’s Spitzer and Swift missions, as well as the Belgian AstroLAB IRIS observatory, astronomers reveal new details on one of the most mysterious stellar objects.

Called KIC 8462852, also known as Boyajian’s Star, or Tabby’s Star, the object has experienced unusual dips in brightness — NASA’s Kepler space telescope even observed dimming of up to 20 percent over a matter of days. In addition, the star has had much subtler but longer-term enigmatic dimming trends, with one continuing today. None of this behavior is expected for normal stars slightly more massive than the Sun. Speculations have included the idea that the star swallowed a planet that it is unstable, and a more imaginative theory involves a giant contraption or “megastructure” built by an advanced civilization, which could be harvesting energy from the star and causing its brightness to decrease.

A new study using NASA’s Spitzer and Swift missions, as well as the Belgian AstroLAB IRIS observatory, suggests that the cause of the dimming over long periods is likely an uneven dust cloud moving around the star. This flies in the face of the “alien megastructure” idea and the other more exotic speculations.

The smoking gun: Researchers found less dimming in the infrared light from the star than in its ultraviolet light. Any object larger than dust particles would dim all wavelengths of light equally when passing in front of Tabby’s Star.

“This pretty much rules out the alien megastructure theory, as that could not explain the wavelength-dependent dimming,” said Huan Meng, at the University of Arizona, Tucson, who is lead author of the new study published in The Astrophysical Journal. “We suspect, instead, there is a cloud of dust orbiting the star with a roughly 700-day orbital period.”

Why Dust is Likely

We experience the uniform dimming of light often in everyday life: If you go to the beach on a bright, sunny day and sit under an umbrella, the umbrella reduces the amount of sunlight hitting your eyes in all wavelengths. But if you wait for the sunset, the sun looks red because the blue and ultraviolet light is scattered away by tiny particles. The new study suggests the objects causing the long-period dimming of Tabby’s Star can be no more than a few micrometers in diameter (about one ten-thousandth of an inch).

From January to December 2016, the researchers observed Tabby’s Star in ultraviolet using Swift, and in infrared using Spitzer. Supplementing the space telescopes, researchers also observed the star in visible light during the same period using AstroLAB IRIS, a public observatory with a 27-inch-wide (68 centimeter) reflecting telescope located near the Belgian village of Zillebeke.

Based on the strong ultraviolet dip, the researchers determined the blocking particles must be bigger than interstellar dust, small grains that could be located anywhere between Earth and the star. Such small particles could not remain in orbit around the star because pressure from its starlight would drive them farther into space. Dust that orbits a star, called circumstellar dust, is not so small it would fly away, but also not big enough to uniformly block light in all wavelengths. This is currently considered the best explanation, although others are possible.

Collaboration with Amateur Astronomers

Citizen scientists have had an integral part in exploring Tabby’s Star since its discovery. Light from this object was first identified as “bizarre” and “interesting” by participants in the Planet Hunters project, which allows anyone to search for planets in the Kepler data. That led to a 2016 study formally introducing the object, which is nicknamed for Tabetha Boyajian, now at Louisiana State University, Baton Rouge, who was the lead author of the original paper and is a co-author of the new study. The recent work on long-period dimming involves amateur astronomers who provide technical and software support to AstroLAB.

Several AstroLAB team members who volunteer at the observatory have no formal astronomy education. Franky Dubois, who operated the telescope during the Tabby’s Star observations, was the foreman at a seat belt factory until his retirement. Ludwig Logie, who helps with technical issues on the telescope, is a security coordinator in the construction industry. Steve Rau, who processes observations of star brightness, is a trainer at a Belgian railway company.

Siegfried Vanaverbeke, an AstroLAB volunteer who holds a Ph.D. in physics, became interested in Tabby’s Star after reading the 2016 study, and persuaded Dubois, Logie and Rau to use Astrolab to observe it.

“I said to my colleagues: ‘This would be an interesting object to follow,'” Vanaverbeke recalled. “We decided to join in.”

University of Arizona astronomer George Rieke, a co-author on the new study, contacted the AstroLAB group when he saw their data on Tabby’s Star posted in a public astronomy archive. The U.S. and Belgium groups teamed up to combine and analyze their results.

Future Exploration

While study authors have a good idea why Tabby’s Star dims on a long-term basis, they did not address the shorter-term dimming events that happened in three-day spurts in 2017. They also did not confront the mystery of the major 20-percent dips in brightness that Kepler observed while studying the Cygnus field of its primary mission. Previous research with Spitzer and NASA’s Wide-field Infrared Survey Explorer suggested a swarm of comets may be to blame for the short-period dimming. Comets are also one of the most common sources of dust that orbits stars, and so could also be related to the long-period dimming studied by Meng and colleagues.

Now that Kepler is exploring other patches of sky in its current mission, called K2, it can no longer follow up on Tabby’s Star, but future telescopes may help unveil more secrets of this mysterious object.

“Tabby’s Star could have something like a solar activity cycle. This is something that needs further investigation and will continue to interest scientists for many years to come,” Vanaverbeke said.

PDF Copy of the Study: Extinction and the Dimming of KIC 8462852

Source: Elizabeth Landau, Jet Propulsion Laboratory

A fellow parent tagged me on a great Facebook thread the other day. Her query echoed a question parents frequently ask me: What do you do when other people’s rules for their kids are different, especially when your kids and their kids are playing on the same digital playground?

“I am getting tired of my sixth-grader (11-year-old) asking for a Snapchat account. She claims all her friends have had one for at least a year or more, and feels embarrassed to tell them she isn’t allowed to when they ask. According to her, and based on the number of her friends with multiple social media accounts, it is the norm in this community to allow middle-school age kids to have Snapchat and other social accounts despite that it is supposed to be restricted from those under the age of 13. Am I being overprotective? Is my daughter really the only one without Snapchat? How do other parents feel about this?”

When it comes to technology and kids, other parents can complicate things. Even if you feel like you’re in control of what happens in your home, the parents of your child’s peers will undoubtedly come into play.

What do you do when other parents have different technology rules for their children?

How many times have you heard, “But all my friends have iPhones!” Or, “Gabe’s mom lets him use Snapchat — why can’t I?” We may have perceived our own parents to be strict or lenient relative to others. What time was your curfew? Were you allowed to have friends over — or to visit their houses unsupervised?

The difference now is that there’s more of a range of opinions and values when it comes to the issues that technology adds to the traditional challenges of parenting. Much of kids’ digital world is about social connections, so the perception of being left out can be heightened in relation to participating in group texting, online games and social media.

What do we do when the parents of our kids’ friends have different rules? How do we manage this in a practical, unemotional way?

Remove judgment: I work with families, and I see how hard it is for parents to talk to other parents about their experiences. There is a lot of judgment and negativity — both internal and external. Doubt creeps in: “Am I doing the right thing?” We are also quick to condemn: “I would never allow that for my kids.” Everyone wants to do right by their kids, and everyone has different values. Start with a little empathy. Try to see it from another parent’s perspective — maybe you will change your view. Regardless, it will help you to understand their choices and to manage the effect it has on your kids.

Communicate openly: If everyone strives for open communication about parenting and technology, and takes a community-oriented approach when we are concerned about children’s behaviour, we’ll all benefit. Most parents are happy to share their experiences. Parenting is difficult, and it’s good to find someone who can relate. It can be reassuring to talk to other parents who have handled a similar situation in a similar way. Take it as your responsibility to start the conversation.

Ditch the guilt: Learn from what other parents are doing, but don’t let the comparison make you feel guilty. I’ve seen shame surface in parents because they think that everyone’s ahead of, or doing better than, them. We each have our own parenting styles. It helps to see what others are doing to establish a frame of reference. But make sure that you are not succumbing to the negative side of comparison. Yes, we all make parenting mistakes — but guilt rarely helps.

 

 

Make confident decisions: Your values are your values. Just as you try not to judge other parents, you should also feel free from incoming judgment. You are a savvy parent with lots of life experiences, and you do what’s right for your family. So feel confident about your choices, and don’t let them be driven by others. As much as you can, don’t let others take these important decisions out of your hands. You are strong and in control — even if it doesn’t seem that way sometimes!

Set “trust milestones”: If your child is claiming to be the last among her peers not to have a cell phone or another device, you can strategise with her about other ways to maintain contact with her friends. Make it clear when you expect her to get a phone and under what conditions. For instance, maybe there’s a “trust milestone” for her to achieve before you’ll grant permission, such as contributing financially to the monthly plan, or adhering to certain rules about its use.

Create a community: Part of being a tech-positive parent is reaching out to others who are thoughtfully engaging in these questions. Find the parents who see themselves as tech-mentors. Is there a mom or dad who knows a lot about Minecraft who can help you set up your personal server? Is there someone at work who feels confident about social media and can coach you on privacy settings so you feel more confident about what your children are sharing (or not sharing) with the world?

How to build your “village”

Dealing with the decisions of other parents can be difficult. We can try to find a more compatible social circle, but our kids choose their friends and we don’t have much control over it. With each new friend come new parents, and new rules that are sure to influence your family.

I look at everything through the lens of mentorship. We are better parents, teachers and community leaders when we mentor our kids. When we teach them to make good decisions, we are empowering them. We need to be good mentors to each other, as well. Take this on. Make the first move. Be the mentor in your community.

Start with one subject that you know really well. Raise a question around the issue. Listen to the comments. Respond thoughtfully. Opening a discussion is the first step.

Use email, a Google group, or a Facebook group, all of which are easy to set up and free. They also allow people to meet virtually and asynchronously, without the hassle of scheduling in-person meetings. Talking face-to-face is valuable, but it can feel like a luxury in our action-packed lives.

There are times when you will wish you could move your kids to another community (or that the parents whose rules you like the least would move far away). Establishing an intentional community can help you feel more empowered around what happens with you and your kids in their digital world, even when the “village” is not making things simple.

Devorah Heitner is the founder of Raising Digital Natives and the author of “Screenwise: Helping Kids Thrive (and Survive) in Their Digital World,” a guide for mentoring digital kids. Her curriculum for grades four to eight is called Connecting Wisely in the Digital Age. She is delighted to be raising her own digital native.

By arrangement with The Washington Post

KUWAIT: Where is the Pokemon? Where is it hiding? How can I catch it? These are questions that are raised by users of the newly-launched Pokemon Go game which has taken the world by storm. The wildly popular mobile app, which is based on a 1990s Nintendo game, has created a global frenzy as players roam the real world looking for virtual cartoon monsters.

The smartphone game, which lets the user hunt virtual creatures called Pokemon in real life via an augmented reality platform, has already dominated download charts in the US and Australia and, drove a lot of young people crazy trying to hunt down these pocket monsters.

Pokemon are spotted in the wild, and are generated based on their geographical habitat. For example, if the Pokemon is a water type, it would be found by the sea. If its type was rock or ground, it would be found near deserts, while grass-type Pokemon are often common in parks or green areas.

People capture the Pokemon and gain experience points to reach higher levels. They have an option of joining one of three teams in the game, which allow the player to conquer gyms that are placed randomly in the environment and compete with other teams.

Pokemon Go is a free-to-play location-based augmented reality mobile game which is developed by Niantic and was released in July 2016 for iOS and Android devices. There are about 9.55 million active users in the US only. Thus it has overcome the active users of twitter and is expected to outgrow every social media.

And if you insist on playing the game, there are many guidelines that you may need to consider while playing including making sure you are wearing appropriate footwear, sneakers or walking shoes that are ideal, ditch the cotton socks as cotton absorbs moisture and get sun protection.

Among the most important tips while using the smart game is to use sunglasses to protect your eyes from UV rays. While the Pokemon players are out hunting for the creatures, they are advised to keep drinking water, particularly during summer, as it is easy to get dehydrated, doing blister patrol, reapplying sunscreen and remaining aware of the surroundings.

No go
In Kuwait, the country has said ‘no’ to Pokemon Go in certain places. The Interior Ministry issued a statement warning users of the smash mobile phone application from taking pictures of any vital government, military or security location. It also warned users not to chase pocket monsters at mosques, shopping centers, malls and oil installations. Interior Ministry’s Undersecretary Lt Gen Suleiman Al-Fahad has warned that there will be no excuses for anyone claiming ignorance of the law.

Kuwait’s Ministry of Communications has also warned smartphone users against downloading popular smartphone game Pokemon Go. Assistant Undersecretary Hamad Al-Qattan said the ministry was discussing ‘means of protection’ from such games with the Communications and Information Technology Authority.

He added that games like Pokemon Go may cause harm to its users in particular and society in general. He pointed out that users of the app might be in danger of potential road accidents if they use the app while driving or crossing roads.

Media Professor at Kuwait University Dr Khaled Al-Qahs said while commenting on the new trend from a media perspective that this game resembles other games that emerge every now and then, expecting the heavy demand on it would diminish with time.

He added that the game has been exploited for a commercial reason and has also conquered the virtual world, saying that the game would have never been given such popularity if the social media outlets did not constitute as an incubator for it.

From a social perspective, Kuwait University’s Sociology Professor Dr Saud Abdulaziz Al-Ghanem argued that once the Pokemon game user starts playing the game, he or she separates from his or her real world and indulges into the virtual world. “He starts running after a picture that only appears on his or her mobile screen, thus, becoming unable to take decisive decisions or actions because of his or her indulgence into the virtual world of the Pokemon,” he said.

Social isolation
Asked about the social dangers that may arise as a result of the game, Dr Saud pointed out that the game users may suffer social isolation for being attached to the game rather than the real world and for searching for virtual creatures which vary in shape and colors, thus, forcing the game users to escape the real world and indulge into the virtual world instead.

However, with the temperature in Kuwait exceeding 50 C degrees in the shade, will the game still be attractive and fascinating to its fans? Young people are seen roaming the streets, mosques, malls and at the sea searching for the little creatures, a matter that can cause unwanted harms.

Though Pokemon Go has not officially come to nations in the Arabian Gulf, many have downloaded the app. Authorities in the United Arab Emirates also have warned users to be careful while chasing digital critters in the augmented reality game.

The game requires the phone to transmit its location via GPS and uses its camera, a matter that prompted the UAE’s Telecommunications Regulatory Authority to warn that the game violates privacy and could lead ‘criminals’ to spread viruses.

Lastly, the Pokemon Go game has really turned the virtual world upside down with millions of people around the world becoming addicted to this game, whereas there are thousands of virtual games which have not got this popularity. – KUNA

So I may have run inside the men's restroom today. No, it wasn't like the ladies' room was full and I had an emergency. But I had to go in there... to catch a Pokemon. Because I wanna be the very best, like no one ever was.

Such is the dilemma faced by Pokémon Go players around the world, and now, in Pakistan.

For those who don't know about Pokémon (because you've been sleeping under a rock for the past two decades), Pokémon, short for Pocket Monsters, is a Nintendo franchise that started out as a video game in 1996 and became a popular TV series that shows a world where these creatures live. The players act as 'trainers'; they have to catch the Pokémon and train them for battles against other trainers.

With the launch of Pokémon GO, old and new Pokémon fans like myself are happy because to catch them is my real test, to train them is my cause. We get to finally travel across the land, searching far and wide (okay okay, I'll stop! But admit it, you were singing it too) - and that too literally!

 

The free-to-play augmented reality game actually has you getting off your seats and running around finding Pokémon. The game transforms your current environment into a fantastical world inhabited by Pokémon. How? It accesses your camera and GPS to place its animated figures in your space.

You're the trainer and your phone is like the glasses that lets you see nearby Pokemon.

I had to have this. I just had to. I grew up on Pokemon! I've played most of the Pokémon games out there, from cards to video games, but this one's different. The draw of Pokémon Go is that it gets me up and moving around, not just sitting in one place with a joypad. Who'd have thought that all you needed to be a Pokemon trainer was a good internet connection and GPS.

 
Twenty minutes in, I was hooked

 

The game is simple in terms of gameplay; your phone shows you if there is a Pokemon nearby and you have to go to that location, and your trainer character moves as you do. Once you locate a Pokémon, you try to catch it by throwing a Poké ball with the flick of your finger. The more Pokémon you catch, the larger your collection and the more you level up as a trainer. You can train your Pokémon, have them battle for you and even trade it with other trainers.

Pokémon Go has not officially been launched in Pakistan, but that's only the first of the challenges of playing the game here.

Here's a little news flash. This is Karachi. Not really the most walking-with-your-phone-out friendly place in the world. And since it is augmented reality, your GPS uses landmarks and turns them into Pokestops (where you replenish your weapons, i.e., Poké balls) and gyms (where you train).

 
Can you guess these locations?

 

Do you know where the nearest pokestop to my place is? A masjid. Yeap. So far, it's either mosques or roundabouts. Considering the security issue, I highly doubt people will be roaming around chowrangis in order to replenish their stock... because... there will be people with guns looking forward to replenish their stock... I did find a way though, just drive by pokestops very slowly.

Another frustration of playing the game in Pakistan? People don't understand why the heck you want to dart into their personal spaces with your phone out. I had a friend begging the manager of a restaurant to let him in the kitchen because there was a Snorlax in there. Another almost went inside Imam Barah because it was showing as a pokestop.

The app also tracks how far you've walked for some tasks, like hatching an egg. That seems rather problematic. A number of female players are annoyed as they have no place to walk around or go out to. I had found a Machamp within my apartments and asked Dad if he wanted to walk with me. He was amused but raised a good question, "What about those kids who don't live in apartment complexes?"

 
Well, they did warn us...

 

Even for guys, let's be honest, no roundabout is secure enough to have your phone out. A number of things can go wrong from mobile snatchers to security at a VIP movement thinking you're up to something. When a friend joked 'good thing jaywalking isn't an issue here,' it genuinely made me concerned about the risk of kids running across the street carelessly. No Charmander is worth running around Boat Basin, people!

But Pokemon Go also has its own charm of playing it in Pakistan. I have friends traveling to Seaview to find water-based Pokemon (GPS does that too, the Pokemon you find will vary with your location) and a park near a cousin's place is a 'gym' so he has been very social with his friends and family because we all need to train there.

I made a trip to the mall and noticed many kids running around staring at their phones and, knowing what they were up to, I asked them why they came there. More than half said they decided to accompany their family's shopping trip. Good job Pokemon, you're bonding families together!

Once the app officially launches here, I'm sure there will be better locations selected. There is also the issue of proper internet connection because sometimes you'll be on a Pokemon's heels and the glitch will have it get away.

The game needs some work in terms of glitches and more gameplay, but it is an amazing experience. My colleagues definitely got a kick out of me running around the office chasing after a Growleth. I don't mind... I know it's my destiny! Yes... I had to...

Overall, I think it's fun and definitely a unique experience. Nintendo definitely found a way to get some exercise into our routines and I can't wait for the official launch 'cause I gotta catch 'em all!

SAN FRANCISCO: Microsoft’s new Windows 10 operating system debuts today, as the longtime leader in PC software struggles to carve out a new role in a world where people increasingly rely on smartphones, tablets and information stored online. No one’s expected to line up overnight for Windows 10, the way people did 20 years ago for Windows 95. But Microsoft is counting on tens or even hundreds of millions of people to download its latest release for free in the coming months. The launch will be accompanied by a global marketing campaign for an event the company hopes will be pivotal – both for its own future and for a vast audience of computer users around the world. Windows 10 is coming to PCs and tablets first, but it’s also designed to run phones, game consoles and even holographic headsets. It has new features, a streamlined Web browser called Edge and a desktop version of Cortana, the online assistant that is Microsoft’s answer to Google Now and Apple’s Siri. Still, the company insists Windows 10 will seem familiar to users of Windows 7, the sixyear- old operating system still running on most PCs. Microsoft and PC makers want to erase the memory of the last big update, 2012’s Windows 8, which alienated many with its jarring, unwieldy design. Microsoft skipped the name Windows 9, as if to distance itself further from the last release. While many analysts believe Windows 8 made sagging PC sales even worse, it’s unclear if Windows 10 will spur the industry back to growth. Here is a look at the launch and why it matters.

What happens this week? Microsoft plans promotional events in several cities today, tied to a global ad campaign and a series of charitable donations. About 5 million people who enrolled in an earlier test program will be able to download Windows 10 right away. The company is also offering Windows 10 as a free download, any time over the next year, to anyone who has the Home or Pro versions of Windows 7 or 8 (but not the Enterprise versions used by big organizations). Some may not get it the first day; Microsoft says it will deliver downloads in waves, to ensure things go smoothly, but it hasn’t said how long that will take. Retailers such as Best Buy, Staples and Wal-Mart will have some desktops and laptops with Windows 10 already installed. More models are coming.

Why is Microsoft giving Windows 10 for free? The company wants to get the new software on as many devices as possible. Microsoft needs a large pool of users to convince independent programmers that it’s worth their time to build useful or entertaining apps for Windows 10 devices. Executives also believe that if people are exposed to the latest and best Windows, they’re more likely to try other Microsoft products on PCs and mobile devices. CEO Satya Nadella says he wants to have 1 billion devices running Windows 10 in three years. Microsoft estimates there are 1.5 billion people who currently use some kind of Windows. Rather than charging them to upgrade, as Microsoft used to do, it’s embracing the free download model pioneered by Apple and Google.

How will Microsoft make money? Microsoft will still collect licensing fees from PC makers that install Windows 10 on new machines. In recent years, most consumers have waited until they bought a new computer to get the latest Windows. Microsoft also makes money from selling Windows and other software to large businesses and organizations. In addition, Microsoft is counting on Windows 10 to spur more use of other services. Microsoft makes money from selling advertising for its Bing search engine, and Windows 10 comes with many apps that steer people to Bing. The company also collects fees from people who use premium versions of its Office software, OneDrive cloud storage and Skype.

Why does this matter to consumers? Microsoft says Windows 10 is designed for the way people use computers today – with a faster Web browser and features that make it easier to start tasks on a PC and then switch to a hand-held device. (Apple and Google tout similar features in their software.) Windows 10 also lets users log in with their face, iris or thumbprint, instead of remembering passwords, though this works only with computers equipped with the right hardware. Most PC users are still working with Windows 7, thanks to Windows 8’s unpopularity. But Microsoft plans to phase out maintenance and security support for Windows 7 over the next five years, and for Windows 8 by 2023, as it did with the older Windows XP. Still, there’s no need to panic about upgrading right away.

Why is it important to the tech industry? The growth in mobile devices has caused PC sales to decline for more than three years, hurting manufacturers like Hewlett-Packard and companies like Microsoft and Intel, whose products are used with PCs. Windows 10 won’t make people give up their hand-held gadgets, but it’s part of Nadella’s strategy to reposition Microsoft for a world where people use multiple devices. PC makers are hoping he succeeds. Jeff Barney, who runs Toshiba’s consumer PC business, said the new software is easier to use than Windows 8 and will complement hardware advances in Toshiba’s newest machines. Although Barney isn’t expecting a big rush to stores today, “over time, I think we’re going to see a positive trend in sales.” — AP

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